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Soursop Facts




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Is Soursop effective in fighting Ebola?

Annonacin, Bullatacin and Asimicin are extremely powerful annonaceous acetogenins isolated from soursop and proven to be highly cytotoxic by numerous scientific studies. There is anecdotal evidence of antiviral action (Herpes, HIV, Hepatitis C) and research studies showing very strong anti cancers properties of the chemical compounds found in Soursop. There are ongoing discussions and suggestions to the infectious disease research community to strongly consider starting trials of Graviola / Soursop extracts  in fighting Ebola Virus Disease (EVD).

If you or someone you know has or has been exposed to EVD and do not have access to approved Ebola medication/vaccine, should you just wait helplessly to die (up to 90% of people sick with EVD die in 7-15 days) or should you give Soursop a try? Are you ready for a 30 day  FREE Trial of  this supplement?

Is Soursop effective in fighting Cancer?

Although no direct evidence or human studies indicating that Soursop fights or cures any form of cancer can be ascertained at this time, a potent group of chemicals from its leaves, bark and seed (called Annonaceous acetogenins) have been successfully isolated. Animal and in-vitro findings using these chemicals were shown to kill or inhibit the growth of various lines of human cancer cells.

Studies and findings

In 1976, Dr. Jerry McLaughlin at Purdue University discovered the ANONACEA GRAVIOLA acetogenins, powerful Anti-Cancer. Continued this research at the National Institute of Cancer proving its effectiveness in cancer colon and prostate. The National Health Center use to other cancers (gastric, kidney and breast). The Faculty of Medicine, Catholic University of Korea conducted comparative studies with adriamycin (chemotherapy) in the treatment of lung cancer.

Studies from 1998 to 2000 by McLaughlin and Chih HW, Chui HF have shown that acetogenins are inhibitors of complex I of oxidative phosphorylation chain thereby block the formation of ATP energy needed by the cancer cell to operate your pump P-glycoprotein mediated, allowing you to stay active. The acetogenins also inhibit the ubiquinone-ubiquinone oxidase, NADH-dependent enzyme that is peculiar to the plasma membrane of the cancer cell. McLaughlin did his research and Bullatacinone Bullatacin acetogenins.

A study from Purdue University in California, showed that acetogenins can selectively inhibit the growth of cancer cells and also inhibit the growth of tumor cells resistant to adriamycin (chemotherapeutic drug). In another study conducted by scientists at the University, it was shown that acetogenins soursop (graviola) are extremely powerful having an ED 50 (lethal dose 50) of up to 10 to 9 micrograms per milliliter, resulting in 10,000 times the potency of Adriamycin.

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Traditional Herbal Medicine

Throughout the Caribbean, in South America, and in parts of Madagascar and Malaysia, Soursop played and is still playing an important role in traditional herbal medicine using different parts or the Soursop plant against different maladies:

Bark: Asthma, cough, ease childbirth, diabetes, flu, hypertension, parasites, muscle spasms. Also used as a heart tonic and a sedative.

Flowers: Coughs and bronchitis

Fruit and Fruit Juice: Primarily used for disorders of the digestive tract – mouth sores, diarrhea, colitis, dysentery. Also used to treat fevers and as a sedative.

Leaves: The most commonly used part of the plant, the leaves of the graviola plant have been traditionally used to treat a wide range of ailments, including: Weakness, asthma, bronchitis, congestion from colds, colic, coughs, diabetes, water retention, dysentery, fever, gallbladder disorders, flu, heart disease, hypertension, indigestion, intestinal parasites, liver ailments, malaria, palpitations, muscle spasms, tumors, ulcers, water retention, and as a general tonic. It is also commonly used as a sedative or tranquilizer.

Externally, leaves are used as a poultice or tincture(or sometimes crushed and mixed with oil) to treat abscesses, boils, swelling, infections, rashes, head lice, ringworm, skin problems, pain from arthritis or rheumatism, nerve pain, or to stop bleeding.The leaves of the soursop plant are also given to new mothers to ease difficult childbirth and to aid in the production of breast milk.

Root and Root bark: The root of Annona muricata is traditionally used as a sedative, to relieve muscle spasms, and to treat diabetes. Seeds: Primarily used as an insecticide and to treat various parasites, including worms, skin parasites and head lice. Also used to relieve gas in the digestive tract and to induce vomiting.

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Side effects- Safety-Drug interactions-Contraindications:


  • Do not take soursoup (graviola) supplements if:
  • You are pregnant – Graviola can trigger premature uterine contractions.
  • If you are breast feeding, as it may be unsafe for your baby.
  • If you have Parkinson’s disease.
  • This supplement should not be taken by anyone under age 18 unless prescribed by a medical professional.
  • Use with caution (or better yet, get your doctor’s OK) if you are allergic to latex – there is some evidence of cross-reactivity between fruits of the custard apple family and latex (“latex-food syndrome.”)

Drug Interactions:

Avoid if you are taking any of the following types of drugs:

  • vasodilators
  • cardiac depressant drugs
  • anti-depressants
  • MAO inhibitors

Caution: Graviola can dangerously increase or decrease the effects of these medications – take only under the direction and supervision of your physician. Dosages of your medication may need to be closely monitored or adjusted.

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Vitamins to Avoid when on Graviola/Soursop cancer / virus adjuvant help 

Vitamin C (taking mega dose of vitamin C is the number one reason that Soursop may be less active against cancer)

Vitamin E


Thyroid support products


CoEnzyme Q10: Taking the supplement CoQ10 (Co-enzyme Q10) along with Soursop may interfere with the effectiveness of Soursop.

“sea greens” such as spirulina, algae, chlorella, kelp may have a problem

The amount of vitamins found in fruits and vegetables will not have a serious effect on the performance of Soursop or Paw Paw.

The following reduce the effects of Soursop:

Burdock Root
Essiac tea and Flor-Essence (which is similar to Essiac with a couple of extra ingredients)
treatments ( oxygen treatments such as hyperbaric oxygen are beneficial to the functioning of Protocel)
Flax seed oil as used in the Budwig diet (also spelled flaxseed oil). It is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution
IP6 (in theory there may be a problem, but case histories are needed)

Hydrogen peroxide
PMB Techno
Rhodiola Rhosea
In higher doses, magnesium is credited with increasing ATP production.
Colloidal silver
– the heavy metal quality of silver could cause a reaction with Protocel.
Pau d’arco with Germanium-132 (taking either separately with Protocel is OK)
Grapefruit seed extract (due to its high vitamin C content)
Whey protein should also be avoided because of the L-cysteine

Cesium Chloride
because of the alpha-lipoic acid
Hormone-Blocking Drugs

MMS (Miracle Mineral Supplement) chlorine dioxide
Sulfhydrazly antioxidants which includes:
Alpha-lipoic acid

Once again the above interactions were observed in cancer trials not as antiviral or antibiotic. Are you ready for a 30 day  FREE Trial of  this supplement?

Side Effects

High dosages may cause nausea and vomiting and/or result in sleepiness or sedation. If this occurs, reduce or discontinue the dosage and notify your doctor.

Long-term use of soursop may reduce “helpful” bacteria in your digestive tract. Consider supplementing with probiotics.

Chronic use of higher than recommended dosages of soursop MAY cause symptoms of neurological damage similar to Parkinson’s disease. Although there is evidence, this connection has yet to be proven, and there may be additional genetic or environmental factors involved. Excessive use of the root, root bark and seeds of the plant should be avoided, as alkaloids in these parts of the plant may be to blame.

Periodic use of graviola (soursop) has NOT been associated with these neurological side-effects. For that reason, it is recommended that you do NOT take this supplement every day if you are taking it long-term. In an article we found, one physician 2 suggests taking it 5 days a week for 3 weeks and then skipping the 4th week, and taking a full month’s break every 3 months. Some users have taken it on weekdays and skipped week-ends. However this is very generic advice – we strongly urge you to seek the advice of your own doctor or qualified medical professional, and follow the label instructions and precautions for any product you are taking.


1. Graviola (Annona muricata) Monograph By Barbara Noller N.D., BHSc., December 2003

2. Graviola supplement research studies, benefits, risks, side effects By Dr. Ray Sahelian MD



Platinum Soursop 100% pure Graviola extract, made in the USA

Soursop (Graviola) Research

A collection of relevant clinical studies which have been conducted on Annona muricata (soursop) and its extract, and several articles on this supplement which were written and/or reviewed by medical professionals.

Last updated: May 25, 2014

Studies – Cancer

Other Medical Research

Additional Resources

Annona muricata – General Research:

Technical Data Report for Graviola
(Download the pdf)

This 2005 document, which includes two resources ( an excerpt from The Healing Power of Rainforest Herbs (2005), by Leslie Taylor and a 2003 monograph by Barbara Noller N.D., BHSc), provides a comprehensive overview of Soursop (Graviola) – its chemical properties, traditional use and the findings of various clinical studies from the mid-1900’s through 2003. Older resource, but highly recommended.

In vitro antioxidant studies in leaves of Annona species.
Indian Journal of Experimental Biology, May 2007

Findings of this study suggest that the extracts of A. muricata possess potent in vitro antioxidant activity

Toxicological evaluation of the lyophilized fruit juice extract of Annona muricata Linn. (Annonaceae) in rodents.
Journal of Basic Clinical Physiology and Pharmacology, December, 2013

The study established that soursop extract did not cause any significant toxic effect in rats following oral administration for 60 consecutive days.

Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of Annona muricata and Piper nigrum against the dengue fever vector Aedes aegypti.
Pest Management Science, May 2013

The extracts of Annona muricata (soursop) and the Piper nigrum fruit may be an inexpensive way to kill the larvae of the Aedes aegypti mosquito – a vector of Dengue fever.



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